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Spinally-injured xCT−/− mice had a faster body weight and motor recovery than wild-type littermates To elucidate the role of System xc− following SCI, wild-type (xCT+/+) and knock-out (xCT−/−) mice were subjected to unilateral cervical contusive injury

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Widely used readouts (4-HNE/MDA adducts, COX-2/PTGS2 induction, transferrin receptor upregulation) lack specificity because they rise in many oxidative or inflammatory states, and TFR1 also increases during iron scarcity (often ferroptosis-resistant), clouding interpretation in tumors and pre-metastatic niches [192]